![]() Potentiate the release of an EV cargo within acceptor cells. That the basic properties of EVs must be modified to act as potentĪt least two steps of the delivery process 1, 5 Several studies, 6− 8 including ours, established that EV cargo delivery within acceptorĬells occurs with a limited efficiency at the basal level. Molecular mechanisms underlying EV uptake andĬontent delivery within the acceptor cell cytosol are still poorlyĬharacterized. Generation of drug delivery systems (DDS). 4 All of these properties make EVs excellent candidates for a new 2 EVs can cross biological barriers such as the Nucleotides, lipids, 1 or synthetic drugs. 1 EVs are involved in many physiological functionsĪnd diseases and can carry several types of cargoes, including proteins, Respectively, secreted directly from the plasma membrane or releasedįrom multivesicular bodies-an endosomal compartment. They include microvesicles and exosomes, which are, Open promising doors in the manufacture of virus-free and EV-basedĮxtracellular vesicles (EVs) are physiologicalĬommunication. These advanced methods and future downstream applications may Toxin responsible for protein translation arrest and acceptor cellĭeath. This method to develop highly potent killer EVs, which contain a lethal We validate our bioengineeredĮVs in a qualitative and quantitative manner. Syncytin-1, an endogenous retrovirus envelop protein with fusogenic Enhanced cargo delivery is promoted by overexpressing Triggers the interaction between a cargo of interest and CD63, a well-established Loading is enabled through a reversible drug-inducible system that Without requirement for any viral fusogenic protein. Here, we develop two synergistic methods to, respectively,Ĭontrol EV cargo loading and enhance EV cargo delivery through fusion ![]() Recent studies suggest that the intrinsic capacities for uptake andĬargo delivery of basic EVs might be too limited to serve as a potentĭelivery system. Types of molecules such as proteins or nucleotides and are long-lastingĬontenders for the establishment of personalized drug delivery systems. Extracellular vesicles (EVs)-including exosomes
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